Method for producing roxithromycin capsules

罗红霉素胶囊的生产方法

Abstract

The invention discloses a method for producing roxithromycin capsules. The production method comprises the following steps: fully mixing raw materials, then sieving the mixture, mixing the sieved materials, and finally filling the mixture with a filling machine to obtain the roxithromycin capsules. The raw materials adopts the following weight proportion: 15 portions of roxithromycin, 0.80 to 0.90portion of sodium carboxymethyl starch, 5.1 to 5.3 portions of soluble starch, 0.1 to 0.3 portion of magnesium stearate and 1.50 to 1.65 portions of superfine silica powder. The method can avoid thecondition that the dissolution rate is usually not quantified during the production of the roxithromycin capsules. The method simplifies the production process and shortens the production period by directly filling the capsules.
本发明公开了一种罗红霉素胶囊的生产方法。该生产方法包含有以下步骤:将原辅料充分混合,然后过筛,再对筛得物进行混合,最后以填充机填充混合物,即得罗红霉素胶囊。所述的原辅料采用以下重量比例:15份罗红霉素、0.80~0.90份羧甲基淀粉钠、5.1~5.3份可溶性淀粉、0.1~0.3份硬脂酸镁和1.50~1.65份微粉硅胶。本发明可以避免罗红霉素胶囊生产过程中经常出现的溶出度不合格的情况。本发明采用直接填充胶囊,简化了生产工序,缩短了生产周期。

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Cited By (4)

    Publication numberPublication dateAssigneeTitle
    CN-102266309-ADecember 07, 2011江苏黄河药业股份有限公司一种新型罗红霉素胶囊及其制备方法
    CN-102920680-AFebruary 13, 2013康普药业股份有限公司一种罗红霉素胶囊及其制备方法
    CN-103083278-AMay 08, 2013四川科伦药物研究有限公司一种罗红霉素胶囊及其制备方法
    CN-103083278-BJune 03, 2015四川科伦药物研究有限公司一种罗红霉素胶囊及其制备方法